Gray hair as well as vitiligo now can be reversed as scientists get to the roots
Gray hair and vitiligo are now able to be reversed at the root, scientists report on May 3, 2013 in a new study published in The Federation of American Societies for Experimental Biology (FASEB) Journal. The research suggests that loss of skin or hair color can be corrected by a new compound -- a pseudocatalase -- that reverses oxidative stress. Gray or white hair can be restored, reversed, and remedied with a topical application known as a "proprietary treatment."
The reversal treatment for gray hair has been recently developed by the researchers who describe it as a topical, UVB-activated compound called PC-KUS. The compound is a modified pseudocatalase.
It's true -- the cure for gray hair is coming. New research in The FASEB Journal shows that people going gray develop oxidative stress via accumulation of hydrogen peroxide in the hair follicle, causing our hair to bleach itself from the inside out. Now, this can be remedied with a proprietary treatment described as a topical, UVB-activated compound called PC-KUS (a modified pseudocatalase).
What's more, the same treatment works for the skin condition, vitiligo. Vitiligo is a condition characterized by patches of unpigmented skin. You can check out the 2013 original study or its abstract, "Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair." It's published in the FASEB Journal. Authors are . M. Wood, H. Decker, H. Hartmann, B. Chavan, H. Rokos, J. D. Spencer, S. Hasse, M. J. Thornton, M. Shalbaf, R. Paus, and K. U. Schallreuter.
Hair dye manufacturers are on notice: The cure for gray hair is coming. That's right, the need to cover up one of the classic signs of aging with chemical pigments will be a thing of the past thanks to a team of European researchers.
White or gray hair bleaches itself naturally from the inside out
In a new research report published online in the FASEB Journal, people who are going gray develop massive oxidative stress via accumulation of hydrogen peroxide in the hair follicle, which causes our hair to bleach itself from the inside out. But most importantly, the report shows that this massive accumulation of hydrogen peroxide can be remedied with a proprietary treatment developed by the researchers described as a topical, UVB-activated compound called PC-KUS (a modified pseudocatalase), according to the May 3, 2013 news release, "Gray hair and vitiligo reversed at the root."
"To date, it is beyond any doubt that the sudden loss of the inherited skin and localized hair color can affect those individuals in many fundamental ways," said Karin U. Schallreuter, M.D., according to a May 3, 2013 news release, "Gray hair and vitiligo reversed at the root." Dr. Schallreuter is the study's author from the Institute for Pigmentary Disorders in association with E.M. Arndt University of Greifswald, Germany and the Center for Skin Sciences, School of Life Sciences at the University of Bradford, United Kingdom. "The improvement of quality of life after total and even partial successful repigmentation has been documented."
Repigmentation of gray or white hair and vitiligo has been shown
To achieve this breakthrough, Schallreuter and colleagues analyzed an international group of 2,411 patients with vitiligo. Of that group, 57 or 2.4 percent were diagnosed with strictly segmental vitiligo (SSV), and 76 or 3.2 percent were diagnosed with mixed vitiligo, which is SSV plus non-segmental vitiligo (NSV).
The researchers found that for the first time, patients who have SSV within a certain nerval distribution involving skin and eyelashes show the same oxidative stress as observed in the much more frequent general NSV, which is associated with decreased antioxidant capacities including catalase, thioredoxin reductase, and the repair mechanisms methionine sulfoxide reductases. These findings are based on basic science and clinical observations, which led to successful patient outcomes regarding repigmentation of skin and eyelashes.
"For generations, numerous remedies have been concocted to hide gray hair," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, according to the news release. "But now, for the first time, an actual treatment that gets to the root of the problem has been developed. While this is exciting news, what's even more exciting is that this also works for vitiligo. This condition, while technically cosmetic, can have serious socio-emotional effects of people. Developing an effective treatment for this condition has the potential to radically improve many people's lives."
Another study done in 2009 described the cause of gray hair
This report follows up on a 2009 study, which gets to the roots of gray hair as scientists find what causes most hair to turn gray and then white as people age. This research report appears in the FASEB Journal which is published by the Federation of American Societies for Experimental Biology.
Wash away your gray? Maybe. A team of European scientists have finally solved a mystery that has perplexed humans throughout the ages: why we turn gray. Despite the notion that gray hair is a sign of wisdom, these researchers show in a research report published online in The FASEB Journal that wisdom has nothing to do with it. Going gray is caused by a massive build up of hydrogen peroxide due to wear and tear of our hair follicles. The peroxide winds up blocking the normal synthesis of melanin, our hair's natural pigment.
Gray and white hair bleach out from hydrogen peroxide from the inside out
"Not only blondes change their hair color with hydrogen peroxide," said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, according to the February 23, 2009 news release, "No longer a gray area: Our hair bleaches itself as we grow older." Further complicating matters, the high levels of hydrogen peroxide and low levels of MSR A and B, disrupt the formation of an enzyme (tyrosinase) that leads to the production of melanin in hair follicles.
Melanin is the pigment responsible for hair color, skin color, and eye color. The researchers speculate that a similar breakdown in the skin could be the root cause of vitiligo. "All of our hair cells make a tiny bit of hydrogen peroxide, but as we get older, this little bit becomes a lot," explains Weissmann, in the news release. "We bleach our hair pigment from within, and our hair turns gray and then white. This research, however, is an important first step to get at the root of the problem, so to speak."
Gray hair caused by the reduction of an enzyme that breaks up hydrogen peroxide and leads to low levels of MSR A and B, which disrupts the formation of an enzyme called tyrosinase
The researchers made this discovery by examining cell cultures of human hair follicles. They found that the build up of hydrogen peroxide was caused by a reduction of an enzyme that breaks up hydrogen peroxide into water and oxygen (catalase). They also discovered that hair follicles could not repair the damage caused by the hydrogen peroxide because of low levels of enzymes that normally serve this function (MSR A and B).
"As any blue-haired lady will attest, sometimes hair dyes don't quite work as anticipated," Weissmann added, according to the 2009 news release. "This study is a prime example of how basic research in biology can benefit us in ways never imagined." You can check out the abstract of the original 2009 study, "Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair." It was published in 2009 in The FASEB Journal. Authors are: J. M. Wood, H. Decker, H. Hartmann, B. Chavan, H. Rokos, J. D. Spencer, S. Hasse, M. J. Thornton, M. Shalbaf, R. Paus, and K. U. Schallreuter.
Also check out the abstract of the study, "Basic evidence for epidermal H2O2/ONOO−-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS." It's published in the FASEB Journal . Authors are Karin U. Schallreuter, Mohammed A. E. L. Salem, Sarah Holtz, and A. Panske.
The FASEB Journal is published by the Federation of American Societies for Experimental Biology. It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.
FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and through collaborative advocacy.